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. 2017 Sep 21;143(2):198–213. doi: 10.1111/jnc.14143

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Published 2017. This article is a U.S. Government work and is in the public domain in the USA. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Microglial activation in the parietal cortex. Activated microglia often associated with degenerating neurons, located in the barrel fields of primary somatosensory cortex layer III, are identified by the dark arrows in panels (d) (METH), (e) (METH+Glucose) and (f) (METH+CORT) and can be compared to the absence of activated microglia in panels (a) (Saline) and (b) (Glucose). There is a hint of slight microglial activation in layer III of the CORT group (panel c). Fewer numbers of such activated microglia can also be seen in cortical layers II and IV as indicated by the gray arrows. Magnification bar (bottom left on panels) = 100 μm.