Table 1.
Functional annotation of the hub genes in ovarian cancer
| Pathways | p-value | FDR q-value |
|---|---|---|
| Pathways in cancer | 2.89E-24 | 5.37E-22 |
| MAPK signaling pathway | 4.17E-16 | 3.88E-14 |
| Wnt signaling pathway | 1.23E-13 | 7.62E-12 |
| p53 signaling pathway | 5.23E-13 | 2.43E-11 |
| Prostate cancer | 3.97E-12 | 1.48E-10 |
| Cell cycle | 4.97E-12 | 1.54E-10 |
| Endocytosis | 9.75E-12 | 2.59E-10 |
| Neurotrophin signaling pathway | 1.81E-11 | 4.20E-10 |
| Apoptosis | 2.12E-11 | 4.38E-10 |
| Small cell lung cancer | 5.05E-11 | 9.40E-10 |
| Leishmania infection | 9.37E-11 | 1.58E-09 |
| Cytokine-cytokine receptor interaction | 3.45E-10 | 5.35E-09 |
| Regulation of actin cytoskeleton | 1.24E-09 | 1.77E-08 |
| Purine metabolism | 1.43E-09 | 1.90E-08 |
| Jak-STAT signaling pathway | 3.27E-09 | 4.06E-08 |
| Ubiquitin mediated proteolysis | 4.10E-09 | 4.77E-08 |
| Toll-like receptor signaling pathway | 8.42E-08 | 9.21E-07 |
| Focal adhesion | 1.06E-07 | 1.09E-06 |
| Pyrimidine metabolism | 1.98E-07 | 1.93E-06 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | 4.40E-07 | 4.09E-06 |
| Amyotrophic lateral sclerosis (ALS) | 4.85E-07 | 4.29E-06 |
| Neuroactive ligand-receptor interaction | 5.23E-07 | 4.42E-06 |
| T cell receptor signaling pathway | 1.02E-06 | 8.22E-06 |
| Alzheimer’s disease | 1.14E-06 | 8.77E-06 |
| Chronic myeloid leukemia | 1.18E-06 | 8.77E-06 |
| Phosphatidylinositol signaling system | 2.08E-06 | 1.49E-05 |
| Tight junction | 2.48E-06 | 1.71E-05 |
| NOD-like receptor signaling pathway | 3.73E-06 | 2.47E-05 |
| Non-small cell lung cancer | 3.85E-06 | 2.47E-05 |
| Melanoma | 4.11E-06 | 2.47E-05 |
| Spliceosome | 4.21E-06 | 2.47E-05 |
| Leukocyte transendothelial migration | 4.24E-06 | 2.47E-05 |
| Axon guidance | 4.78E-06 | 2.69E-05 |
| Lysosome | 6.29E-06 | 3.44E-05 |
| Glioma | 6.73E-06 | 3.58E-05 |
| B cell receptor signaling pathway | 8.37E-06 | 4.33E-05 |
| Oocyte meiosis | 9.39E-06 | 4.72E-05 |
| Base excision repair | 9.77E-06 | 4.73E-05 |
| VEGF signaling pathway | 9.92E-06 | 4.73E-05 |
| Epithelial cell signaling in Helicobacter pylori infection | 1.17E-05 | 5.44E-05 |
| Endometrial cancer | 1.44E-05 | 6.53E-05 |
| Colorectal cancer | 1.94E-05 | 8.58E-05 |
The p-value and FDR q-value was provided by GSEA, which was applied to evaluate the significance of the enrichment analysis