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. Author manuscript; available in PMC: 2018 Jan 11.
Published in final edited form as: Sci Signal. 2013 May 14;6(275):ra35. doi: 10.1126/scisignal.2003708

Fig. 2. USP25 restricts LPS-induced septic shock as well as production of proinflammatory cytokines in vivo.

Fig. 2

(A to D) Age- and sex-matched 7- to 8-week-old wild-type (WT) and Usp25−/− littermates (five mice each) were injected intraperitoneally with LPS. Two and a half hours later, the serum amounts of (A) IL-6, (B) TNF-α, (C) CXCL1, and (D) IFN-α were determined by enzyme-linked immunosorbent assay (ELISA). Data are means ± SD of three independent experiments. *P < 0.05 by t test. (E) USP25-deficient mice exhibit increased susceptibility to LPS-induced septic shock. WT and Usp25−/− littermates were treated with LPS as in (A). The survival of the mice was monitored over the next 48 hours. Data are combined from two independent experiments and are from a total of 10 mice of each genotype.