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. Author manuscript; available in PMC: 2018 Aug 8.
Published in final edited form as: Cell Rep. 2017 Aug 8;20(6):1269–1277. doi: 10.1016/j.celrep.2017.07.031

Figure 4. P. histicola challenge caused shift in gut microbiota.

Figure 4

A) HLA-DR3.DQ8 transgenic mice with EAE had a distinct gut microbiome profile compared to those from pre-immunized (naïve mice). The P. histicola treated group had gut microbiota profile similar to pre-immunized (naïve mice) group. Weighted UniFrac-based 3D PCoA plot based on all OTUs from fecal samples of mice from, pre-immunized (n=6), medium treated EAE group (n=11), and P. histicola treated group (n=6). B) Relative abundance of gut microbiota at the genus levels in pre-immunized (naïve mice), EAE mice treated with medium, and EAE mice treated with P. histicola. C) Box plot showing normalized relative abundance of bacteria (genus-level profile) showing difference between groups. Mice with EAE had loss of certain genera especially Prevotella, Sutterella, and Lactobacillus compared to pre-immunized (naïve) mice. P. histicola challenge restored abundance of Prevotella, Sutterella, and Lactobacillus. The difference between groups were analyzed using one-way ANOVA (Kruskal-Wallis rank sum test) and FDR-adjusted p<0.05.