Table 6.
Top 10 significant drugs identified by DrugMatrix in Enricher
| Candidate drugs | Overlap | P-value | Adjusted P-value |
|---|---|---|---|
| Prednisolone-184_mg/kg_in_Water-Rat-Heart-5d-dn | 53/343 | 1.10E-28 | 4.34E-25 |
| Ethosuximide-1200_mg/kg_in_Water-Rat-Heart-3d-dn | 50/319 | 2.16E-27 | 5.66E-24 |
| Caffeine-93_mg/kg_in_Water-Rat-Heart-3d-dn | 51/345 | 1.07E-26 | 1.69E-23 |
| Clomipramine-115_mg/kg_in_Water-Rat-Heart-3d-dn | 49/320 | 2.19E-26 | 2.55E-23 |
| Prednisolone-184_mg/kg_in_Water-Rat-Heart-3d-dn | 53/340 | 7.07E-29 | 4.34E-25 |
| Gatifloxacin-770_mg/kg_in_Corn_Oil-Rat-Heart-1d-dn | 48/315 | 9.12E-26 | 7.19E-23 |
| Vinorelbine-1.5_mg/kg_in_Saline-Rat-Heart-1d-dn | 51/351 | 2.45E-26 | 2.55E-23 |
| Atropine-94_mg/kg_in_Water-Rat-Heart-5d-dn | 51/353 | 3.22E-26 | 2.82E-23 |
| Vinorelbine-1.5_mg/kg_in_Saline-Rat-Heart-3d-dn | 47/305 | 1.83E-25 | 1.31E-22 |
| Oxymetazoline-0.5_mg/kg_in_Water-Rat-Heart-5d-dn | 48/325 | 3.77E-25 | 2.47E-22 |
Drug names, concentrations, solvents, period after treatment, and up- or downregulation (dn) are listed. Overlap means the number of genes among the 457 genes identified by TD-based unsupervised FE