Table 2. DEGs clusters modulated by purified isoflavone mix (MI) stimulate MCF-7 tumor growth in ovariectomized athymic nude mice.
DEGs in the cluster from 1 to 5 are up-regulated. DEGs in the cluster from 6 to 26 are down-regulated.
| Cluster | Differentially Expressed Genes (DEGs) |
|---|---|
| 1 | RAB31, PCDH11X /// PCDH11Y, CDC42EP5 |
| 2 | GNB4, NEIL3, NPY1R, F12, MYB, ANKRD34A, MYBL1, EGR3 |
| 3 | RPS21, PRRG1, KIF14, ZNF883, LOC401397, MRTO4, CHAC2, KIAA1524 |
| 4 | TAF9B, PCDHA9, KIF23 |
| 5 | TMEM45A, ANXA6 |
|
| |
| 6 | STAT1, TACSTD2, TMPRSS2, ASAH1, APLP2, TM4SF1, FGFR2 |
| 7 | CD74, TAPBP, ATP2A3 |
| 8 | NDRG2, C10orf81 |
| 9 | FBXL16, MICAL2, APLP2, HLA-G, HLA-C, HLA-A /// HLA-F /// HLA-J, HLA-B |
| 10 | CLU, EPAS1, PPAP2B, TLR2, JAG1 |
| 11 | STEAP1, ARL4C |
| 12 | STEAP2, GPC4, PLBD1 |
| 13 | EHF, PGCP |
| 14 | SGPP2, CAPN2, LAMP3 |
| 15 | ABCA1, ABCC4, IGFBP3 |
| 16 | KLK14, APOD |
| 17 | LOC100288985, MBNL2 |
| 18 | JAM3, SPARC, RUNX1T1 |
| 19 | IGDCC3, FILIP1L, NEDD4L |
| 20 | ARHGEF40, RBMS1, STC1 |
| 21 | ZNF503, CYBB, HIPK2, COL1A1, HLA-F, VIPR1, GNAS, HLA-A, PPAP2B, MUC20, RBM17, QKI |
| 22 | EBF1, HLA-B, ZNF423, CCDC80, VIM, KLF13, PPAP2B, LOC652147, CDH11 |
| 23 | RNF5, NEDD4L, MEIS2 |
| 24 | NFIX, LOXL1, COL1A2, GABBR1 /// UBD |
| 25 | CLU, TSPAN1 |
| 26 | TNFRSF19 |