Table II.
Alterations in body weight and blood glucose in mice.
| 72 h after STZ injection | Prior to sacrifice | |||
|---|---|---|---|---|
| Group | Body weight (g) | Blood glucose (mmol/l) | Body weight (g) | Blood glucose (mmol/l) |
| N | 23.55±1.21 | 8.4±1.68 | 29.4±1.59 | 9.75±1.84 |
| N + Scsi | 23.37±1.75 | 8.9±1.20 | 29.2±1.37 | 10.15±1.24 |
| N + FGF21si | 23.26±1.47 | 9.63±0.67 | 29.09±1.46 | 10.48±0.94 |
| DCM | 23.73±2.05 | 20.93±2.03a | 22±1.16a | 24.21±2.65a |
| DCM + Scsi | 22.98±1.12 | 21.67±1.98 | 21.83±1.2 | 23.9±2.18 |
| DCM +FGF21si | 23.11±1.85 | 21.84±2.11a | 21.54±0.96a | 29.79±4.48b |
a
P<0.05 vs. N group
b
P<0.05 vs. DCM group. Data were analyzed by one-way analysis of variance, followed by a post hoc Turkey's test. Values are reported as the mean ± standard deviation. N, normal; DCM, diabetic cardiomyopathy; Scsi, scrambled siRNA; FGF21si, FGF21 siRNA; FGF21, fibroblast growth factor 21; STZ, streptozotocin.