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. 2017 Oct 24;15(1):191–197. doi: 10.3892/etm.2017.5370

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Copyright: © Qin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Knockdown of MDC1 abolishes the suppressive effect of MDC1-AS on cell metastasis in human gastric cancer cells. (A) Representative images of Transwell assays with MKN28 cells after MDC1-AS-expressing plasmid treatment with or without siMDC1. (B) Quantification of Transwell assays with MKN28 cells revealed that migration was increased by MDC1-AS-expressing plasmid treatment and that this effect was inhibited by siMDC1 treatment. (C) Representative images of Transwell assays with MKN45 cells after shMDC1-AS treatment with or without MDC1-expressing plasmid treatment. (D) Quantification of Transwell assays demonstrated that cell migration was inhibited by shMDC1-AS and this effect was relieved by MDC1-expressing plasmid treatment. *P<0.05 vs. the control group. MDC1, mediator of DNA damage checkpoint protein 1; MDC1-AS, MDC1-antisense RNA; shMDC1-AS, small hairpin RNA directed against MDC1-AS; siMDC1, small interfering RNA directed against MDC1.