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. 2017 Oct 23;15(1):377–382. doi: 10.3892/etm.2017.5349

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Figure 3. — Simvastatin decreased the apoptosis of neurons in the intracerebral hemorrhage animals. (A) A TUNEL assay and the quantified apoptotic rate indicated a reduced rate of apoptosis in simvastatin-treated animals. (B) Western blot analysis of the expression levels of AQP4, MMP-9, caspase-3 and Bcl-2 in neuronal cells in experimental mice. Simvastatin treatment significantly downregulated the expression levels of AQP4, MMP-9 and caspase-3. Whereas it significantly upregulated the protein expression of Bcl-2. **P<0.01. AQP4, aquaporin-4; MMP-9, matrix metallopeptidase 9; Bcl-2, B-cell lymphoma-2.