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. 2018 Jan 10;18:68. doi: 10.1186/s12885-017-3948-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Differential gene expression of LCN2 in thyroid tumours and normal tissues. Gene expression was measured in follicular thyroid adenoma (FTA), follicular thyroid cancer (FTC), follicular variant of papillary thyroid carcinoma (FVPTC), papillary thyroid carcinoma (PTC), normal thyroid tissues and thyroid cancer cell lines by real-time quantitative PCR. Histogram showing the gene expression of each sample ordered by expression levels (a). Box plot representation (median and Tukey whiskers) showing gene expression of each subgroup of thyroid tumours – FTA, FTC, FVPTC and PTC (b). Gene expression of the thyroid cancer cell lines (c). Gene expression was calibrated by the pool of normal thyroid tissues. Statistically significant values: *P = 0.013 **P < 0.001