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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Physiol Behav. 2017 Mar 16;176:17–25. doi: 10.1016/j.physbeh.2017.03.019

Figure 4.

Figure 4

LV Exendin-4 does not alter cocaine-evoked dopamine signaling in the NAc shell. (A) Time-dependent effects of vehicle (open gold circles) and Exendin-4 (closed gold circles) on dopamine signaling (CV Matches) across a session of 30 intravenous cocaine infusions. Vehicle (n=7) or Exendin-4 (n=7) was administered after 10 cocaine infusions (denoted by the broken vertical line). (B) Statistical comparison of the Average CV Matches across bins of 5 cocaine infusions. There is no statistical difference (p>0.05) between Vehicle (white bars) and Exendin-4 treated rats (gold bars) over the course of the session. Bars represent group means for the 4 minutes preceding cocaine infusion (cocaine infusion 0) or binned cocaine infusions periods. Error bars are ± 1 standard error of the mean (SEM). (C) NAc shell recording sites depicted as circles (gold open= vehicle, gold filled= Exendin-4) on coronal sections modified from Paxinos and Watson (2007). Numbers on the left indicate approximate distance of the section from bregma.