Table 3.
Relative risk of comorbidities and multimorbidity in 345 patients with Sarcoidosis in 1976–2013 compared to 345 subjects without Sarcoidosis according to time after incidence/index date
| First 5 years only | After 5 years only | |
|---|---|---|
| Comorbidity | Hazard ratio (95% CI)* | Hazard ratio (95% CI)* |
| Hypertension | 1.92 (1.04, 3.53) | 1.02 (0.73, 1.42) |
| Congestive heart failure | 18.33 (2.43, 138.53) | 1.37 (0.79, 2.37) |
| Coronary artery disease | 2.33 (0.96, 5.66) | 1.38 (0.86, 2.23) |
| Arrhythmia | 1.89 (0.92, 3.86) | 1.34 (0.96, 1.88) |
| Hyperlipidemia | 1.90 (1.18, 3.06) | 1.06 (0.79, 1.42) |
| Cerebrovascular (stroke or transient ischemic attack) | 10.06 (1.29, 78.67) | 1.87 (1.00, 3.50) |
| Arthritis (rheumatoid arthritis or osteoarthritis) | 2.36 (1.38, 4.03) | 1.23 (0.91, 1.67) |
| Asthma | 2.18 (0.82, 5.82) | 1.50 (0.84, 2.69) |
| Cancer | 0.78 (0.21, 2.92) | 0.55 (0.28, 1.09) |
| Chronic kidney disease | 2.08 (0.78, 5.54) | 1.33 (0.82, 2.17) |
| Chronic obstructive pulmonary disease | 2.03 (0.98, 4.21) | 1.01 (0.65, 1.55) |
| Dementia/Alzheimer’s disease | 1.50 (0.25, 8.97) | 0.77 (0.35, 1.69) |
| Depression | 2.00 (1.04, 3.85) | 1.36 (0.87, 2.13) |
| Diabetes | 1.02 (0.54, 1.91) | 1.75 (1.24, 2.48) |
| Hepatitis | -- | -- |
| Major osteoporotic fracture | 3.15 (0.85, 11.66) | 1.85 (0.96, 3.57) |
| Schizophrenia | 2.15 (0.39, 11.76) | 1.19 (0.46, 3.10) |
| Substance abuse disorder | 1.55 (0.44, 5.49) | 0.63 (0.29, 1.38) |
| ≥2 chronic conditions | 2.44 (1.58, 3.78) | 1.34 (1.01, 1.77) |
| ≥3 chronic conditions | 1.59 (1.03, 2.45) | 1.28 (0.98, 1.67) |
| ≥4 chronic conditions | 1.92 (1.21, 3.04) | 1.26 (0.95, 1.67) |
| ≥5 chronic conditions | 3.40 (1.77, 6.55) | 1.24 (0.92, 1.68) |
*
adjusted for age, sex and calendar year of sarcoidosis/index date
Abbreviation: CI, confidence interval