Table 2.
Univariable and multivariable models showing relationships between intervention, Rett Syndrome Gross Motor Scale (RSGMS) scores (n = 12) and blood brain derived neurotrophic factor (BDNF) levels (n = 10) adjusting for relevant confounders
| Outcomes | Coefficient (95%CI) | P value | Coefficient (95%CI) | P value | Coefficient (95%CI) | P value |
|---|---|---|---|---|---|---|
| Univariable model (n = 12) | Multivariable model – 1 (n = 12) | Multivariable model – 2 (n = 10) | ||||
| RSGMS | ||||||
| Treatment after 2 months | 2.7 (0.8, 4.6) | 0.01 | 3.4 (1.5, 5.3) | 0.001 | ||
| Treatment after 4 months | 4.6 (2.2, 7.0) | < 0.001 | 5.7 (3.3, 8.2) | < 0.001 | ||
| Treatment after 6 months | 6.6 (3.7, 9.5) | < 0.001 | 8.2 (5.1, 11.2) | < 0.001 | 10.29 (3.20, 17.38) | 0.004 |
| Age (year) | 1.0 (−3.1, 5.2) | 0.63 | −1.6 (−6.0, 2.9) | 0.492 | −0.12 (−4.70, 4.47) | 0.960 |
| Age at regression (month) | 1.1 (0.1, 2.2) | 0.028 | 1.06 (0.07, 2.05) | 0.035 | ||
| Blood BDNF (time-varying) | −0.01 (−0.03, 0.01) | 0.412 | ||||
| Univariable model (n = 10) | Multivariable model (n = 10) | |||||
| Blood BDNF | ||||||
| Treatment after 6 months | 342.9 (297.0, 388.8) | < 0.001 | 321.4 (272.0, 370.8) | < 0.001 | ||
| Age (year) | 30.1 (10.7, 49.5) | 0.002 | 39.0 (15.6, 62.4) | 0.001 | ||
| Age at regression (month) | −4.8 (−10.4, 0.9) | 0.098 | ||||
| RSGMS (time-varying) | 2.4 (−0.6, 5.4) | 0.119 | ||||