Table 3.
Univariable and multivariable findings for relationships between treatment, BMI and other secondary behavioural outcomes (n = 12)
| Outcomes | Univariable model | Multivariable model | ||
|---|---|---|---|---|
| Coefficient (95%CI) | P value | Coefficient (95%CI) | P value | |
| BMI | ||||
| Treatment after 2 months | −0.5 (−1, 0.0) | 0.042 | −0.6 (−1.2, −0.1) | 0.026 |
| Treatment after 4 months | −0.4 (−1.0, 0.2) | 0.157 | −0.6 (−1.3, 0.1) | 0.096 |
| Treatment after 6 months | 0.0 (−0.6, 0.6) | 0.938 | −0.3 (−1.2, 0.6) | 0.49 |
| Age (years) | −0.3 (−0.9, 0.3) | 0.333 | −0.3 (−1.1, 0.5) | 0.519 |
| Age at regression (months) | 0.0 (−0.2, 0.2) | 0.707 | ||
| Gross motor assessment score (time-varying) | 0.0 (0.0, 0.1) | 0.307 | ||
| Sleep Disturbance Scale for Children - DIMS subscale | ||||
| Treatment after 2 months | 0.4 (−1.8, 2.6) | 0.73 | 0.2 (−2.1, 2.4) | 0.892 |
| Treatment after 4 months | 0.3 (−2.1, 2.7) | 0.81 | 0.1 (−2.4, 2.6) | 0.961 |
| Treatment after 6 months | 0.1 (−2.4, 2.6) | 0.93 | 0 (−2.8, 2.8) | 0.998 |
| Age (years) | −2.6 (−4.7, −0.6) | 0.01 | −2.2 (−4.8, 0.3) | 0.082 |
| Age at regression (months) | −0.1 (−0.7, 0.4) | 0.6 | ||
| Sleep hygiene score | −0.1 (−0.3, 0.2) | 0.567 | ||
| Rett Syndrome Behaviour Questionnaire – Mood subscale | ||||
| Treatment after 2 months | −0.1 (−1.8, 1.6) | 0.921 | −0.2 (−2.0, 1.5) | 0.804 |
| Treatment after 4 months | −0.2 (−2.0, 1.7) | 0.874 | −0.4 (−2.3, 1.5) | 0.691 |
| Treatment after 6 months | 1 (−0.9, 2.9) | 0.31 | 0.7 (−1.3, 2.7) | 0.496 |
| Age (years) | −0.8 (−2.1, 0.6) | 0.275 | −0.2 (−1.7, 1.4) | 0.789 |
| Age at regression (months) | −0.2 (−0.5, 0.2) | 0.316 | ||