Table 1.
Characteristics of AML patients with (AML-cytopenic) and without (AML-non-cytopenic) prior cytopenia at the time their CBC was drawn.
| AML-cytopenic (n = 29) | AML-non-cytopenic (n = 111) | p-Value | |
|---|---|---|---|
| Age at AML diagnosis, median (range) | 71 (37–93) | 65 (21–88) | 0.001 |
| Gender (M:F) | 18:11 | 56:55 | 0.30 |
| Co-morbidities that may be associated with anemia or thrombocytopenia | 6/29 | 14/111 | 0.37 |
| Cardiac valvular disease | 0 | 4 | |
| Beta thalassemia trait | 1 | 1 | |
| Chronic lymphocytic leukemia | 1 | 1 | |
| Gastrointestinal bleeding history | 2 | 1 | |
| Autoimmune disease | 0 | 4 | |
| Status post solid-organ transplant | 1 | 1 | |
| Chronic renal failure | 0 | 1 | |
| Chronic hepatitis B infection | 1 | 0 | |
| Von Willebrand disease | 0 | 1 | |
| Months between prior CBC and AML diagnosis, median (range) | 10 (6–35) | 12 (6–35) | 0.36 |
| Circumstances of visit when CBC was obtained | 0.65 | ||
| Routine primary care visit | 9 (31%) | 30 (27%) | |
| Medical condition | 10 (34%) | 42 (38%) | |
| Surgery or surgical follow-up | 3 (10%) | 16 (14%) | |
| Emergency room/trauma | 4 (14%) | 6 (5%) | |
| Obstetric visit/delivery | 1 (3%) | 1 (1%) | |
| Unknown | 2 (7%) | 15 (14%) | |
| Hematocrit, %, median (range) | 35.0 (29.3–41.5) | 40.8 (26.2–49.0) | <0.0001 |
| Mean corpuscular volume, fL, median (range) | 95 (61–126) | 90 (67–110) | 0.022 |
| Platelet count, ×109/L, median (range) | 129 (30–397) | 237 (150–685) | <0.0001 |
| White blood count, ×109/L, median (range) | 4.8 (2.3–16.5) | 6.8 (2.1–51.9a) | 0.014 |
a
Patient with white blood count of 51.9 × 109/L had concomitant chronic lymphocytic leukemia.