Fig. 4.

E1E2-matched HCVcc and HCVpp show the same hierarchy of neutralization resistance to a panel of broadly neutralizing antibodies targeting distinct epitopes. Representative neutralization curves for H77 and 1b09 (natural isolate) HCVcc and HCVpp. E1E2-matched HCVcc and HCVpp were tested for sensitivity to neutralization by serial dilutions of anti-HCV bNAbs or non-specific IgG. Colours indicate bNAb tested (dark blue, CBH-5; red, HC84.26; green, HC84.22; purple, HC33.4; orange, AR3A). Error bars indicate sd between duplicate wells. IC₅₀ results for all E1E2/bNAb combinations tested with full mAb dilution curves for both HCVcc and HCVpp are summarized in Table 1, and all neutralization curves are shown in Fig. S1.