Table 1.

CpG sites showing the greatest differential methylation between the no-recurrence and the recurrence/progression tumours.

cg ID	Direction of methylation	Recurrence and/or progression	Sensitivity, %	Specificity, %	Positive predictive value, %	Negative predictive value, %
cg04415176	Hyper	12/14	85.7	100.0	100.0	77.8
cg06391663	Hyper	12/14	85.7	100.0	100.0	77.8
cg19457237	Hyper	12/14	85.7	100.0	100.0	77.8
cg06607594	Hyper	12/14	85.7	100.0	100.0	77.8
cg01392017	Hyper	12/14	85.7	100.0	100.0	77.8
cg13322920	Hyper	12/14	85.7	100.0	100.0	77.8
cg17180705	Hyper	12/14	85.7	100.0	100.0	77.8
cg11850659	Hyper	13/14	92.9	100.0	100.0	87.5
cg12228319	Hyper	13/14	92.9	100.0	100.0	87.5
cg18916488	Hyper	12/14	85.7	100.0	100.0	77.8
cg12539415	Hypo	13/14	92.9	100.0	100.0	87.5
cg12050358	Hypo	12/14	85.7	100.0	100.0	77.8
cg19182537a	Hypo	11/14	78.6	100.0	100.0	70.0
cg14729962	Hypo	12/14	85.7	100.0	100.0	77.8
cg04382470	Hypo	12/14	85.7	100.0	100.0	77.8
cg01149192	Hypo	12/14	85.7	100.0	100.0	77.8
cg00397479	Hypo	12/14	85.7	100.0	100.0	77.8
cg03540028	Hypo	12/14	85.7	100.0	100.0	77.8
cg22328426	Hypo	13/14	92.9	100.0	100.0	87.5
cg27084746	Hypo	12/14	85.7	100.0	100.0	77.8

Top 20 sites (with CG identifier) of differential methylation between the clinical outcomes of high-risk non-muscle invasive bladder cancer. The direction of methylation change in the recurrence/progression tumours is stated relative to the no-recurrence tumours, with the number of tumours showing differential methylation at each site shown. The values for sensitivity, specificity, and positive and negative predictive values of tumour recurrence/progression are given on the right side of the table.

^acg19182537 was included with the candidates showing differential methylated 12 or more recurrence/progression tumours of 14, as methylation in one of the recurrence/progression tumours was very close to the differential methylation threshold used.