Table 4.
Effects of Trimester 1 and 2 and Year 1 NO2 exposures adjusted for each othera
| Time Point | Adjustmentb | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Trimester 1 | Trimester 2 | Year 1 | |||||
| betac | 95% CI | betac | 95% CI | betac | 95% CI | ||
|
|
|||||||
| VABS Composite Score | Trimester 1 | −7.56% | (−11.9%, −0.80%)* | −5.38% | (−11.7%, 2.75%) | −3.26% | (−9.50%, 4.07%) |
| Trimester 2 | −3.97% | (−10.6%, 3.95%) | −7.93% | (−13.1%, −0.23%)* | 0.44% | (−9.31%, 10.2%) | |
| Year 1 | −11.8% | (−16.6%, −3.18%)* | −15.1% | (−22.2%, −3.09%)* | −14.6% | (−20.9%, −3.71%)* | |
|
| |||||||
| VABS Communication Subscale | Trimester 1 | −8.57% | (−16.0%, −1.01%)* | −6.63% | (−16.4%, 3.26%) | −2.90% | (−12.0%, 6.36%) |
| Trimester 2 | −3.55% | (−13.3%, 6.38%) | −8.43% | (−17.1%, 0.35%) | 3.66% | (−9.49%, 17.1%) | |
| Year 1 | −15.5% | (−24.5%, −6.40%)* | −21.6% | (−34.3%, −8.71%)* | −18.0% | (−29.5%, −6.38%)* | |
|
| |||||||
| VABS Dependent Living Subscale | Trimester 1 | −5.09% | (−11.0%, 0.81%) | −3.17% | (−10.8%, 4.55%) | −1.82% | (−8.98%, 5.41%) |
| Trimester 2 | −3.50% | (−11.1%, 4.21%) | −5.83% | (−12.6%, 1.00%) | 0.05% | (−10.2%, 10.4%) | |
| Year 1 | −8.95% | (−16.0%, −1.80%)* | −10.6% | (−20.7%, −0.38%)* | −10.6% | (−19.6%, −1.38%)* | |
|
| |||||||
| VABS Socialization Subscale | Trimester 1 | −8.40% | (−14.8%, −1.92%)* | −6.70% | (−15.1%, 1.76%) | −6.16% | (−14.0%, 1.78%) |
| Trimester 2 | −3.11% - | (−11.5%, 5.40%) | −8.05% | (−15.5%, −0.52%)* | −3.62% | (−14.9%, 7.84%) | |
| Year 1 | 6.19% | (−14.0%, 1.75%) | −8.0% | (−19.3%, 3.34%) | −11.7% | (−21.7%, −1.51%)* | |
|
| |||||||
| VABS Motor Skills Subscale | Trimester 1 | −2.21 | (−5.16, 0.73) | −1.51 | (−5.34, 2.33) | −0.88 | (−4.47, 2.71) |
| Trimester 2 | −1.28 | (−5.12, 2.55) | −2.40 | (−5.81, 1.01) | 0.14 | (−5.00, 5.27) | |
| Year 1 | −3.66 | (−7.25, −0.07)* | −4.59 | (−9.73, 0.55) | −4.45 | (−9.06, 0.16) | |
|
| |||||||
| MSEL DQ composite | Trimester 1 | −4.92 | (−8.65, −1.19)* | −3.70 | (−8.56, 1.15) | −2.09 | (−6.61, 2.44) |
| Trimester 2 | −2.20 | (−7.06, 2.65) | −4.94 | (−9.27, −0.61)* | 0.85 | (−5.63, 7.33) | |
| Year 1 | −7.75 | (−12.3, −3.22)* | −10.49 | (−17.0, −4.01)* | −9.62 | (−15.4, −3.81)* | |
|
| |||||||
| MSEL DQ verbal | Trimester 1 | −6.30 | (−10.6, −2.04)* | −4.91 | (−10.5, 0.63) | −2.99 | (−8.15, 2.18) |
| Trimester 2 | −2.52 | (−8.06, 3.02) | −6.15 | (−11.1, −1.20)* | 0.78 | (−6.62, 8.18) | |
| Year 1 | −9.08 | (−14.3, −3.92)* | −12.6 | (−20.0, −5.15)* | −11.8 | (−18.4, −5.12)* | |
|
| |||||||
| MSEL DQ non verbal | Trimester 1 | −3.53 | (−7.15, 0.08) | −2.49 | (−7.20, 2.21) | −1.19 | (−5.59, 3.20) |
| Trimester 2 | −1.88 | (−6.59, 2.82) | −3.73 | (−7.92, 0.46) | 0.92 | (−5.37, 7.20) | |
| Year 1 | −6.41 | (−10.8, −2.02)* | −8.42 | (−14.7, −2.13)* | −7.48 | (−13.1, −1.84)* | |
|
| |||||||
| ADOS CSS | Trimester 1 | −0.03 | (−0.29, 0.24) | −0.15 | (−0.49, 0.19) | −0.18 | (−0.50, 0.14) |
| Trimester 2 | 0.22 | (−0.12, 0.57) | 0.11 | (−0.19, 0.42) | −0.07 | (−0.53, 0.39) | |
| Year 1 | 0.42 | (0.10, 0.74) | 0.33 | (−0.13, 0.79) | 0.26 | (−0.15, 0.67) | |
a
Shaded diagonal represents the main effect for each time point. Each time point (row) was then adjusted for an additional time point (column) for each test score
b
All models were adjusted for sex, max education in the home, referral center, race, mother’s age, prenatal smoking, season of conception and home ownership
c
Pollutant effects were scaled to 6.82 ppb for NO2 (2 SD of the distribution of the pregnancy average exposure)
*
p<0.05