Figure 2. OIM mice have increased frequency of myeloid lineage cells in bone marrow.

The frequency of different cell populations within the bone marrow of 7-week old WT and OI mice was evaluated by flow cytometry (n=5–6). Data are shown for (A) Lin⁻ Sca1⁺ cKit⁺ (LSK) hematopoietic progenitor cells; (B) common lymphoid progenitors (CLP), Lin⁻ Sca1⁺ cKit^int IL7R⁺; (C) B cells, B220⁺; (D) common myeloid progenitors (CMP), Lin− Sca1⁻ cKit⁺ CD34⁺ CD16^lo; (E) granulocyte macrophage progenitors (GMP), Lin⁻ Sca1⁻ cKit⁺ CD34⁺ CD16^hi; (F) megakaryocyte erythroid progenitors (MEP), Lin⁻ Sca1⁻ cKit⁺ CD34⁻ CD16⁻; (G) myeloid cells, CD11b⁺; (H) granulocytes, Ly6G⁺; and (I) erythrocyte progenitors, Ter119⁺. * p<0.05 compared to WT control.