Table 1.

Murine Models of HFpEF Classified by Aging and Comorbidities Seen in HFpEF Patients (Hypertension, Obesity and Diabetes, Atrial Fibrillation, Pulmonary Hypertension, and Renal Insufficiency)

Comorbidity	Animal Models	HFpEF Pathophysiology					HFpEF	Ref. #
		LV Structure	Systolic Function	Diastolic Function	Pulmonary Congestion	Exercise Intolerance
Aging	Fisher 344 rat	Eccentric hypertrophy	Mild dysfunction	Diastolic dysfunction	Yes	Yes	☹	33, 38, 39, 40, 42, 43
	SAMP8 mouse	Not described	Preserved to reduced	Diastolic dysfunction	No	Yes	☹	49, 50, 51
Hypertension	Aldosterone-infused uninephrectomized mouse	Concentric hypertrophy	Preserved	Diastolic dysfunction	Yes	Yes	☺	68, 70, 71, 72, 73, 74
	Angiotensin II-infused mouse	Concentric and dilated hypertrophy	Preserved	Diastolic dysfunction	Yes	Yes	☺	16, 81, 82, 84, 85, 86, 89, 90, 91
	Dahl salt-sensitive rat	Concentric to eccentric hypertrophy	Preserved to reduced	Diastolic dysfunction	Yes	Yes	☹	95, 96, 97, 98
	DOCA salt rat	Concentric hypertrophy	Preserved	Diastolic dysfunction	Not described	Not described	?	107, 108
	Spontaneously hypertensive rat	Concentric to eccentric hypertrophy	Preserved to reduced	Diastolic dysfunction	Yes	Yes	☹	119, 120, 121, 122
	Transverse aortic constriction-induced pressure overload mouse	Concentric to eccentric hypertrophy	Preserved to reduced	Diastolic dysfunction	Yes	Yes	☹	70, 127, 128, 129
Obesity and diabetes	db/db mouse	Concentric hypertrophy	Preserved	Diastolic dysfunction	Yes	Yes	☺	152, 155, 159, 160, 161, 162, 163, 164, 165
	ob/ob mouse	Concentric hypertrophy	Preserved	Diastolic dysfunction	Not described	+/−	?	175, 176, 177, 178, 185
	Streptozotocin-induced diabetic rat	Eccentric hypertrophy or heart atrophy	+/−	Diastolic dysfunction	+/−	Not described	☹	191, 195, 196, 197, 200, 203, 204, 207, 208, 212, 213
	ZSF1rat	Concentric hypertrophy	Preserved	Diastolic dysfunction	Yes	Yes	☺	226, 228, 229, 231
Atrial fibrillation	Genetic model	None or eccentric hypertrophy	Mild dysfunction	Not described	Not described	Not described	?	(245)
Pulmonary hypertension	Hypoxia-induced pulmonary hypertension	Concentric hypertrophy	Preserved	Not described	Not described	Not described	?	267, 268
Renal insufficiency	Subtotal nephrectomy rat	Concentric to eccentric hypertrophy	Preserved to reduced	Diastolic dysfunction	Yes	Yes	☹	275, 277, 278, 279, 281, 282

☺ = HFpEF phenotype; ☹ = not a HFpEF phenotype; HFpEF = heart failure with preserved ejection fraction.