Table 3.
Murine Models: Pathophysiology of Obesity and Diabetes-Associated HFpEF Based on the Existing Literature
| Findings in Obesity and Diabetes-Associated Human HFpEF 53, 139 | db/db Mouse | ob/ob Mouse | Streptozotocin- Induced Diabetic Rat | ZFS1 Rat |
|---|---|---|---|---|
| Obesity | Yes | Yes | No | Yes |
| Insulin resistance or diabetes | Yes | Yes | Yes | Yes |
| Fatigue/exercise intolerance | Yes | +/− | N/A | Yes |
| Edema | Yes | N/A | +/− | Yes |
| Concentric hypertrophy or increased LV mass | Yes | Yes | +/− | Yes |
| Arterial stiffness | Yes | Yes | Yes | Yes |
| Disturbed ventricular-arterial coupling | Yes | N/A | Yes | N/A |
| Cardiomyocyte hypertrophy | Yes | Yes | Yes | Yes |
| Myocardial fibrosis | Yes | Yes | Yes | Yes |
| Decreased intra-myocardial capillary density | Yes | +/− | Yes | No |
| Natriuretic peptides levels | ↓ | =/↓ | ↑ | N/A |
| Systemic inflammation | Yes | N/A | Yes | N/A |