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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Aug 26;1865(11 Pt B):1643–1653. doi: 10.1016/j.bbapap.2017.08.008

Figure 2.

Figure 2

Kinetic models describing the activator effect of NS1643 drug on hERG channel. Closed states (C1 to C3), Open state (O), Inactivated state (I) and drug bound states (D subindex) are connected and constrained by experimental data. kon-C, kon-O are the drug association rates constants in the closed, open states, respectively. koff-C, koff-O are the dissociation rate constants in the closed and open states, respectively. The rest of the rate constants describing transitions between the unbound/bound states were modeled according to the previously Markov Model proposed by Wang et al.[135].