Table 2. Genotypes of circadian rhythm genes for SCS MS consortium.
| Genotypes | Total control (%) | Total MS (%) | χ2 | P corr. | OR [95% confidence interval] | ||
|---|---|---|---|---|---|---|---|
| rs3789327 | CC | 198 (19.68) | 257 (29.11) | 22.89 | 7.49∙10–5 | CC/CT+TT 1.68 [1.35–2.07], P = 0,0001 |
|
| CT | 489 (48.61) | 375 (42.47) | |||||
| TT | 319 (31.71) | 251 (28.43) | |||||
| rs1481892 | CC | 93 (9.57) | 73 (9.97) | 0.16 | 1.00 | GG/CC+GC 1.02 [0.84–1.23] |
|
| GC | 424(43.62) | 313 (42.76) | |||||
| CC | 455 (46.81) | 346 (47.27) | |||||
| rs4757144 | AA | 280 (31.67) | 190 (27.54) | 3.28 | 1.00 | GG/AA+AG 1.04 [0.81–1.32] |
|
| GA | 422 (47.74) | 354 (51.30) | |||||
| GG | 182 (20.59) | 146 (21.16) | |||||
| rs6811520 | CC | 598 (64.09) | 512 (72.01) | 11.75 | 0.02 | CC/CT+TT 1.40 [1.13–1.73], P = 0,002 |
|
| CT | 274 (29.37) | 166 (23.35) | |||||
| TT | 61 (6.54) | 33 (4.64) | |||||
| rs6850524 | CC | 151 (15.07) | 138 (15.94) | 2.38 | 1.00 | GG/CC+GC 1.12 [0.93–1.36] |
|
| GC | 502 (50.10) | 403 (46.54) | |||||
| GG | 349 (34.83) | 325 (37.53) | |||||
| rs11932595 | AA | 306 (33.89) | 250 (30.38) | 4.96 | 0.59 | GG/AA+AG 1.3 [1.02–1.67] |
|
| GA | 450 (49.83) | 397 (48.95) | |||||
| GG | 147 (16.28) | 164 (20.22) | |||||
| rs13124436 | AA | 88 (11.47) | 83 (10.81) | 0.36 | 1.00 | GG/AA+AG 1.06 [0.86–1.29] |
|
| GA | 336 (43.81) | 331 (43.10) | |||||
| GG | 343 (44.72) | 354 (46.09) | |||||