Table 1. Characteristics of patients according to estimated tropism.
| Predicted tropism | ||||
|---|---|---|---|---|
| R5 | X4 | p-value | Total | |
| N = 888 | N = 249 | N = 1137 | ||
| Gender, n(%) | 0.558 | |||
| Female | 181 (20.4%) | 55 (22.1%) | 236 (20.8%) | |
| Age, years | 0.020 | |||
| Median (IQR) | 37 (30, 45) | 40 (32, 47) | 38 (31, 46) | |
| Mode of HIV Transmission, n(%) | 0.030 | |||
| PWID | 51 (5.7%) | 27 (10.8%) | 78 (6.9%) | |
| MSM | 416 (46.8%) | 109 (43.8%) | 525 (46.2%) | |
| Heterosexual contacts | 359 (40.4%) | 92 (36.9%) | 451 (39.7%) | |
| Other/Unknown | 62 (7.0%) | 21 (8.4%) | 83 (7.3%) | |
| Nationality, n(%) | 0.292 | |||
| Italian | 727 (81.9%) | 211 (84.7%) | 938 (82.5%) | |
| HBsAg, n(%) | 0.114 | |||
| Negative | 802 (90.3%) | 235 (94.4%) | 1037 (91.2%) | |
| Positive | 12 (1.4%) | 1 (0.4%) | 13 (1.1%) | |
| Not tested | 74 (8.3%) | 13 (5.2%) | 87 (7.7%) | |
| HCVAb, n(%) | 0.723 | |||
| Negative | 778 (87.6%) | 216 (86.7%) | 994 (87.4%) | |
| Positive | 59 (6.6%) | 20 (8.0%) | 79 (6.9%) | |
| Not tested | 51 (5.7%) | 13 (5.2%) | 64 (5.6%) | |
| Hepatitis co-infection, n(%) | 0.376 | |||
| No | 735 (82.8%) | 212 (85.1%) | 947 (83.3%) | |
| Yes | 71 (8.0%) | 21 (8.4%) | 92 (8.1%) | |
| Not tested | 82 (9.2%) | 16 (6.4%) | 98 (8.6%) | |
| AIDS diagnosis, n(%) | 0.152 | |||
| Yes | 80 (9.0%) | 30 (12.0%) | 110 (9.7%) | |
| Time from HIV diagnosis to date of CRT test, years | 0.933 | |||
| Median (IQR) | 1.71 (1.66, 1.78) | 1.72 (1.66, 1.77) | 1.72 (1.66, 1.78) | |
| CD4 count, cells/mmc | 0.066 | |||
| Median (IQR) | 439 (291, 602) | 404 (201, 580) | 433 (275, 587) | |
| CD4 count nadir, cells/mmc | < .001 | |||
| Median (IQR) | 397 (249, 538) | 284 (119, 448) | 369 (205, 521) | |
| CD8 count, cells/mmc | 0.780 | |||
| Median (IQR) | 907 (640, 1254) | 870 (579, 1305) | 905 (624, 1275) | |
| Viral load, log10 copies/mL | 0.887 | |||
| Median (IQR) | 4 (3, 5) | 4 (2, 5) | 4 (3, 5) | |
| ART exposure status | 0.851 | |||
| Naive | 523 (58.9%) | 145 (58.2%) | 668 (58.8%) | |
| Experienced | 365 (41.1%) | 104 (41.8%) | 469 (41.2%) | |
| Diabetes, n(%) | 0.711 | |||
| Yes | 18 (2.0%) | 6 (2.4%) | 24 (2.1%) | |
| Method used for tropism testing | 0.152 | |||
| Trofile | 236 (26.6%) | 55 (22.1%) | 291 (25.6%) | |
| Geno2pheno | 652 (73.4%) | 194 (77.9%) | 846 (74.4%) | |
| Follow-up (months) | 0.694 | |||
| Median (IQR) | 34.1 (14.0, 57.6) | 36.2 (17.7, 58.8) | 34.5 (14.8, 58.1) | |
Chi-square or Kruskal-Wallis test were applied as appropriate
Legend: IQR: interquartile range; PWID: People Who Inject Drugs; MSM: men who have sex with men; CRT: co-recptor tropism; ART: antiretroviral therapy