Table 3. Relative hazard of time to FIB4 progression.
| Relative hazards of time to Fib4 progression | ||||
|---|---|---|---|---|
| Unadjusted RH(95% CI) | p-value | Adjusted RH(95% CI) | p-value | |
| Tropism | ||||
| R5 | 1.00 | 1.00 | ||
| X4 | 0.99 (0.70, 1.40) | 0.952 | 0.86 (0.59, 1.26) | 0.444 |
| Mode of HIV Transmission | ||||
| PWID | 1.00 | 1.00 | ||
| MSM | 0.61 (0.35, 1.05) | 0.076 | 1.05 (0.62, 1.76) | 0.776 |
| Heterosexual contacts | 0.69 (0.40, 1.19) | 0.188 | 0.86 (0.52, 1.42) | 0.868 |
| Calendar year of test | ||||
| per more recent | 1.13 (1.06, 1.20) | < .001 | 0.76 (0.44, 1.32) | 0.324 |
| Age, years | ||||
| per 10 years older | 1.44 (1.25, 1.65) | < .001 | 1.40 (1.20, 1.64) | < .001 |
| CD4 count, cells/mmc | ||||
| <200 | 1.00 | 1.00 | ||
| 201–350 | 0.53 (0.27, 1.06) | 0.074 | 0.68 (0.29, 1.61) | 0.383 |
| >350 | 0.52 (0.31, 0.89) | 0.018 | 1.07 (0.51, 2.24) | 0.850 |
| Unknown | 0.65 (0.39, 1.10) | 0.106 | 0.85 (0.23, 3.07) | 0.799 |
| CD4 count nadir, cells/mmc | ||||
| <200 | 1.00 | 1.00 | ||
| 201–350 | 0.67 (0.44, 1.03) | 0.071 | 1.04 (0.61, 1.76) | 0.887 |
| >350 | 0.64 (0.45, 0.92) | 0.015 | 1.00 (0.60, 1.67) | 0.986 |
| Unknown | 1.15 (0.49, 2.70) | 0.756 | 1.08 (0.39, 2.77) | 0.867 |
| Viral load, log10 copies/mL | ||||
| <5000 | 1.00 | 1.00 | ||
| 5000–10000 | 0.85 (0.33, 2.19) | 0.741 | 1.21 (0.44, 3.34) | 0.708 |
| 10000–100000 | 0.99 (0.58, 1.69) | 0.972 | 1.42 (0.79, 2.61) | 0.257 |
| >100000 | 1.46 (0.86, 2.48) | 0.158 | 2.05 (1.13, 3.81) | 0.022 |
| Unknown | 1.22 (0.79, 1.90) | 0.374 | 1.89 (0.53, 6.80) | 0.332 |
| Aids diagnosis | ||||
| Yes vs. No | 1.70 (1.08, 2.67) | 0.021 | 1.65 (0.97, 2.80) | 0.066 |
| ART exposure status | ||||
| Not Naïve | 1.00 | 1.00 | ||
| Naïve | 0.69 (0.50, 0.94) | 0.018 | 0.63 (0.43, 0.94) | 0.024 |
| Time from HIV diagnosis to date of tropism test | ||||
| per more recent | 1.01 (1.01, 1.02) | < .001 | 1.04 (0.99, 1.09) | 0.114 |
| HCV infection | ||||
| No | 1.00 | 1.00 | ||
| Yes | 2.23 (1.43, 3.49) | < .001 | 3.30 (1.92, 5.67) | < .001 |
| Not tested | 0.87 (0.33, 2.29) | 0.779 | 0.65 (0.24, 1.73) | 0.387 |
| Diabetes | ||||
| Yes vs. No | 3.47 (1.54, 7.78) | 0.003 | 3.63 (1.54, 8.62) | 0.003 |
Adjusted for a number of factors measured at the time of tropism test—mode of HIV transmission, nationality, AIDS diagnosis, B/C co-infection status, calendar year, age, CD4 count, CD4 nadir, HIV-RNA, diabetes, use of lipids/blood pressure lowering drugs, ART exposure status and stratified by clinical site.