Table 4.
OprD genotype classification of 45 strains
| Resistance phenotype Number of strains | Number of strains | Stop codon site | Large deletion site (nt) |
|---|---|---|---|
| IPM(R) MEM(R) | |||
| 17 | 1 | 150 | – |
| 3 | 624 | 561–624 | |
| 1 | 624 | – | |
| 1 | 714 | – | |
| 1 | 912 | – | |
| 1 | 951 | 816–855 | |
| 3 | 1035 | – | |
| 3 | 1302 | – | |
| 1 | – | 561–624 | |
| 2 | – | ||
| IPM(R) MEM(S) | |||
| 8 | 4 | 281 | – |
| 1 | 906 | 862–866 | |
| 1 | 1119 | – | |
| 2 | 1302 | – | |
| IPM(S) MEM(R) | |||
| 5 | 2 | 219 | – |
| 1 | 381 | – | |
| 1 | 354 | – | |
| 1 | – | 1116–1118, 1147–1149 | |
| IPM(S) MEM(S) | |||
| 15 | 2 | 162 | – |
| 1 | 219 | – | |
| 1 | 693 | – | |
| 1 | 699 | – | |
| 8 | 1296 | 1116–1118, 1147–1149, 1288–1292 | |
| 1 | 1302 | 348–350, 1147–1149, 1288–1292 | |
| 1 | 1302 | – |
Notes: Forty-five strains were randomly selected: 17 IPM- and MEM-resistant strains, 8 IPM-resistant and MEM-susceptible strains, 5 IPM-susceptible and MEM-resistant strains, and 15 strains with susceptibility to carbapenem used as controls. The sequences were compared with the wild-type PAO1 sequence. “–” Represents “no”.
Abbreviations: IPM, imipenem; MEM, meropenem.