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. 2018 Jan 11;13(1):e0191038. doi: 10.1371/journal.pone.0191038

Fig 2. The effect of Hamp1 deletion in murine M.tb infection and iron-related hepatic gene expression.

Fig 2

Female 16–20 week old Hamp1-/- mice and wild type controls were infected with 50–100 CFU of M.tb Erdman strain via aerosol (A). Animals were sacrificed 4 weeks later and CFU enumerated in organ homogenates (B-C). Hepatic gene expression is shown for Fpn1 (D), Id1 (E), Bmp6 (F), Tfrc (G), Ftl (H) and Fth (I). Mann-Whitney tests were performed to compare groups where *, **, ***, and **** indicate p = <0.05, p = <0.01, p = <0.001 and p = <0.0001, respectively. N = 10 animals per group. Closed circles represent wild type animals and open circles represent Hamp1-/- animals.