Table 2. GWAS associations with parents' attained age phenotypes.
| P-values for phenotype: | Effect for the analysis in bold | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lead SNP | CHR | BP | A1 | A0 | Parents' attained age | Parents' age at death | Both parents top 10% | Mothers' attained age | Fathers' attained age | A1F | Beta | SE | Implicated gene(s) | ||
| Combined parents' age results | |||||||||||||||
| Common & in GWAS catalogue of findings | |||||||||||||||
| rs602633 | 1 | 109821511 | T | G | 2.7E-08 | 2.9E-03 | 2.4E-03 | 2.1E-03 | 3.6E-09 | 0.217 | −0.0150 | 0.0027 | CLESR2 … PSRC1 | ||
| rs28383322 | 6 | 32592796 | C | T | 5.3E-11 | 9.8E-03 | 2.0E-04 | 3.5E-09 | 2.0E-04 | 0.783 | 0.0182 | 0.0028 | HLA-DRB1… HLA-DQA1 | ||
| rs55730499 | 6 | 161005610 | C | T | 1.7E-18 | 5.4E-11 | 2.7E-08 | 5.5E-10 | 5.9E-17 | 0.920 | −0.0361 | 0.0041 | LPA | ||
| rs1556516 | 9 | 22100176 | G | C | 4.7E-16 | 1.5E-10 | 2.5E-08 | 8.7E-05 | 1.3E-20 | 0.502 | −0.0181 | 0.0022 | CDKN2B-AS1 (ANRIL) | ||
| rs7137828 | 12 | 111932800 | C | T | 3.4E-14 | 3.1E-08 | 3.2E-06 | 2.2E-07 | 2.7E-12 | 0.483 | 0.0170 | 0.0022 | SH2B3/ATXN2 | ||
| rs1317286 | 15 | 78896129 | A | G | 1.2E-26 | 1.8E-11 | 4.0E-09 | 2.1E-07 | 1.5E-31 | 0.668 | −0.0254 | 0.0024 | CHRNA3 | ||
| rs17514846 | 15 | 91416550 | C | A | 7.1E-10 | 6.6E-07 | 2.0E-04 | 7.8E-04 | 1.2E-07 | 0.530 | −0.0139 | 0.0023 | FURIN | ||
| rs429358 | 19 | 45411941 | T | C | 1.4E-74 | 5.0E-22 | 7.1E-46 | 1.3E-68 | 1.9E-28 | 0.845 | −0.0566 | 0.0031 | APOE/APOC1 | ||
| Common | |||||||||||||||
| rs1627804 | 6 | 107400428 | C | A | 1.1E-04 | 4.0E-08 | 4.5E-06 | 5.7E-03 | 2.4E-04 | 0.684 | 0.0197 | 0.0035 | BEND3 | ||
| rs7844965 | 8 | 27442064 | G | A | 7.7E-09 | 1.5E-04 | 6.0E-04 | 4.9E-04 | 2.2E-07 | 0.768 | 0.0154 | 0.0027 | EPHX2 | ||
| rs61978928 | 14 | 75321714 | T | C | 2.0E-08 | 7.7E-05 | 3.3E-07 | 1.0E-04 | 1.9E-07 | 0.688 | 0.0136 | 0.0024 | PROX2 | ||
| rs28926173 | 18 | 13886719 | G | A | 6.4E-06 | 2.4E-05 | 2.3E-08 | 2.4E-04 | 2.5E-02 | 0.953 | −0.0264 | 0.0047 | MC2R | ||
| Rare (<2%) | |||||||||||||||
| rs146254978 | 1 | 74867799 | T | C | 2.1E-02 | 4.6E-08 | 1.9E-03 | 4.3E-01 | 3.0E-04 | 0.980 | −0.0692 | 0.0126 | FPGT/TNNI3K | ||
| rs139137459 | 11 | 119269958 | G | A | 5.3E-03 | 1.1E-01 | 2.7E-08 | 3.0E-02 | 3.1E-02 | 0.996 | −0.0906 | 0.0162 | USP2-AS1 | ||
| Loci only emerging in mothers' analysis | |||||||||||||||
| rs3130507 | 6 | 31147476 | G | A | 3.5E-06 | 6.1E-02 | 8.9E-01 | 2.1E-10 | 2.4E-01 | 0.720 | −0.0155 | 0.0024 | PSORS1C3 … [x] | ||
| 13:31871514 | 13 | 31871514 | T | G | 5.6E-04 | 4.5E-01 | 7.0E-01 | 4.7E-08 | 3.4E-01 | 0.995 | 0.0979 | 0.0180 | B3GALTL | ||
| rs61949650 | 13 | 64836488 | T | C | 4.2E-05 | 1.5E-03 | 1.5E-03 | 2.9E-08 | 6.7E-01 | 0.938 | 0.0251 | 0.0045 | (intergenic) | ||
| Loci only emerging in fathers' analysis | |||||||||||||||
| rs3131621 | 6 | 31425499 | A | G | 8.9E-08 | 1.9E-02 | 4.8E-01 | 3.5E-05 | 3.6E-08 | 0.629 | −0.0124 | 0.0022 | MICA … MICB | ||
| rs13262617 | 8 | 59838133 | A | G | 9.6E-03 | 7.3E-03 | 1.3E-01 | 8.1E-01 | 3.1E-08 | 0.970 | 0.0360 | 0.0064 | TOX | ||
| rs61905747 | 11 | 113639842 | A | C | 3.6E-05 | 3.5E-02 | 7.0E-02 | 2.2E-01 | 5.5E-09 | 0.809 | −0.0160 | 0.0028 | ZW10 | ||
| rs74011415 | 15 | 47660194 | G | A | 7.0E-06 | 3.9E-02 | 2.6E-02 | 5.0E-02 | 1.4E-08 | 0.881 | −0.0192 | 0.0034 | SEMA6D | ||
| rs12461964 | 19 | 41341229 | A | G | 1.8E-04 | 1.5E-01 | 7.8E-01 | 4.8E-01 | 8.2E-09 | 0.504 | −0.0126 | 0.0022 | EGLN2 … CYP2A6 | ||
| rs74444983 | 19 | 45745607 | T | C | 4.1E-05 | 9.1E-03 | 1.1E-01 | 6.9E-02 | 9.1E-09 | 0.741 | −0.0143 | 0.0025 | EXOC3L2 … MARK4 | ||
| rs6108784 | 20 | 10964366 | T | C | 7.7E-04 | 4.3E-01 | 5.7E-02 | 7.8E-01 | 1.2E-10 | 0.586 | −0.0143 | 0.0022 | C20orf187 | ||
| rs2273500 | 20 | 61986949 | T | C | 4.4E-07 | 8.9E-02 | 1.8E-01 | 3.8E-03 | 1.5E-08 | 0.856 | −0.0176 | 0.0031 | CHRNA4 | ||
Lead SNP = SNP with lowest p-value in 1Mb region
BP = Genomic position, build 37 (hg19), A1F = frequency of A1, the effect allele, P = BOLT LMM p-value (A1F, BETA, and SE are for p-value in bold), SE = Standard Error
Beta = A1 effect on outcome. For attained age (Martingale residuals) a negative BETA = reduced hazard, i.e. increased attained age
Implicated gene(s) = Variants in locus usually intronic, or exonic (indicated by underlining). If two genes separated by dots, the SNP is intergenic