Table 3. Clinicopathological characteristics of enrolled patients divided among four age groups.
| Age groups | |||||
|---|---|---|---|---|---|
| Characteristics | Very young | Young | Premenopausal | Postmenopausal | P value |
| (< 35) | (36–40) | (41–50) | (>50) | ||
| No. of patients | 15 | 37 | 47 | 46 | |
| Age at diagnosis (yrs) | |||||
| Mean (±SD) | 33.4 (1.7) | 38.0 (1.4) | 45.8 (2.5) | 59.2 (6.4) | < 0.0001* |
| Median (range) | 34 (30–35) | 38 (36–40) | 46 (41–50) | 58 (51–72) | |
| Tumor size (cm) | |||||
| Mean (±SD) | 2.6 (1.9) | 2.3 (1.0) | 2.1 (1.5) | 2.0 (1.0) | 0.448 |
| Median (range) | 2.5 (0.9–9.0) | 2.2 (0.2–4.3) | 1.9 (0.1–7.3) | 2.0 (0.6–5.4) | |
| Axillary LN status | |||||
| Positive | 8 (53.3) | 16 (43.2) | 15 (31.9) | 21 (45.7) | 0.389 |
| Negative | 7 (46.7) | 21 (56.8) | 32 (68.1) | 25 (54.3) | |
| TNM stage | |||||
| I | 4 (26.7) | 10 (27.0) | 25 (53.2) | 17 (37.0) | 0.072 |
| II | 6 (40.0) | 21 (56.8) | 13 (27.7) | 16 (34.8) | |
| III | 5 (33.3) | 6 (16.2) | 9 (19.1) | 13 (28.2) | |
| ER | |||||
| Positive | 8 (53.3) | 25 (67.6) | 40 (85.1) | 28 (60.9) | 0.030* |
| Negative | 7 (46.7) | 12 (32.4) | 7 (14.9) | 18 (39.1) | |
| PR | |||||
| Positive | 8 (53.3) | 25 (67.6) | 38 (80.9) | 18 (39.1) | < 0.001* |
| Negative | 7 (46.7) | 12 (32.4) | 9 (19.1) | 28 (60.9) | |
| HER2/neu | |||||
| Positive | 8 (53.3) | 11 (29.7) | 9 (19.1) | 15 (32.6) | 0.082 |
| Negative | 7 (46.7) | 25 (70.3) | 38 (80.9) | 31 (67.4) | |
| Combined ER/PR status | |||||
| +/+ | 8 (53.3) | 23 (62.2) | 37 (78.7) | 18 (39.1) | 0.002* |
| +/− | 0 | 2 (5.4) | 3 (6.4) | 10 (21.8) | |
| −/+ | 0 | 2 (5.4) | 1 (2.1) | 0 | |
| −/− | 7 (46.7) | 10 (27.0) | 6 (12.8) | 18 (39.1) | |
| Tumor subtype | |||||
| Luminal A (ER+ and/or PR+, HER2-) | 4 (26.7) | 17 (46.0) | 36 (76.6) | 22(47.9) | 0.006* |
| Luminal B (ER+ and/or PR+, HER2+) | 4 (26.7) | 10 (27.0) | 5 (10.6) | 7 (15.2) | |
| HER2-overexpression (ER-, PR-, HER2+) | 4 (26.7) | 2 (5.4) | 3 (6.4) | 10 (21.7) | |
| Triple negative (ER-, PR-, HER2-) | 3 (19.9) | 8 (21.6) | 3 (6.4) | 7 (15.2) | |
Data are presented as the mean ± SD or number (%).
* P < 0.05 by chi-square test.