Table 2. Plasma protein binding for compounds 4, 5, and the control drug propranolol.
Compound | Conc. (μM) | Mouse plasma protein binding (%) |
---|---|---|
Propranolol HCl | 4 | 71.6 ± 9.3 |
4 | 20 | 46.6 ± 8.7 |
4 | 40.1 ± 6.4 | |
0.8 | 46.0 ± 11.1 | |
5 | 20 | 41.4 ± 7.6 |
4 | 40.9 ± 4.5 | |
0.8 | 35.0 ± 8.8 |