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. 2018 Jan 11;13(1):e0191231. doi: 10.1371/journal.pone.0191231

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© 2018 Thålin et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) Quantification of H3Cit showed increased levels in patients with advanced cancer compared to both healthy individuals and severely ill patients without known cancer. No significant difference in the levels of plasma H3Cit between severely ill patients without known cancer and healthy individuals were observed. (B) Plasma levels of H3Cit were significantly higher in patients with adenocarcinomas compared to patients with tumors of other histopathologies and (C) in patients with spread cancer compared to patients with localized tumors. (D) The levels of plasma cfDNA were significantly higher in cancer patients compared to both healthy individuals and severely ill patients without known cancer. The levels were also significantly higher in severely ill patients without known cancer compared to healthy individuals. (E) A significant positive correlation was found between plasma levels of H3Cit and cfDNA in cancer patients and in severely ill patients without known cancer. Lines represent medians with IQR. Groups were compared with the Mann-Whitney U test. Significance of correlation was analyzed with Pearson correlation coefficient after log transformed data to obtain a normal distribution. NS P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.