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. 2018 Jan 11;13(1):e0191231. doi: 10.1371/journal.pone.0191231

Fig 3. Inflammatory cytokines are elevated and correlate with H3Cit in patients with advanced cancer.

Fig 3

(A-E) Plasma levels of IL-8, IL-6, TNFα, IL-1β, and G-CSF were all significantly higher in cancer patients compared to healthy individuals, as well as to severely ill patients without known cancer, with the exception of G-CSF which was similarly elevated in cancer patients and severely ill patients without known cancer. (F) Plasma levels of H3Cit correlated to plasma levels of IL-8 and IL-6, but weaker or no correlations were found to TNFα, IL-1β and G-CSF. (G) Multivariable regression confirmed the predictive influence of plasma cfDNA, NE, MPO, MPO-DNA complexes, IL-8, and IL-6 on plasma H3Cit levels (p<0.001). VIP, variable influence on projection. Lines represent medians with IQR. Groups were compared with the Mann-Whitney U test. Significance of correlation was analyzed with Pearson correlation coefficient after log transformed data to obtain a normal distribution. NS P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.