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. 2018 Jan 11;13(1):e0191231. doi: 10.1371/journal.pone.0191231

Fig 4. Prognostic value of high levels of plasma H3Cit, NE, IL-8 and IL-6 in patients with advanced cancer.

Fig 4

Kaplan-Meier curves and survival analyses with the log rank test obtaining HR were performed to assess associations between laboratory markers and short-term (100 days) mortality. Patients with plasma H3Cit (A) levels above the 75th percentile presented with a 2-fold increased risk for short-term mortality compared with patients with plasma levels below the 75th percentile (P = 0.02). Increased levels of cfDNA (B) lacked prognostic significance (P = 0.24). Increased levels of NE (C) displayed a similar prognostic significance as high levels of plasma H3Cit (P<0.001). High levels of MPO (D) and MPO-DNA complexes (E) lacked prognostic significance (P = 0.39). The inflammatory cytokines IL-8 (F) and IL-6 (G) were also strongly associated with short-term mortality (P = 0.001 and <0.001 respectively). There was no significant association between high levels of TNFα (H), IL-1β (I) and G-CSF (J) and short-term mortality (P = 0.10, 0.12 and 0.27 respectively).