. Author manuscript; available in PMC: 2019 Feb 7.

Published in final edited form as: J Theor Biol. 2017 Nov 15;438:34–45. doi: 10.1016/j.jtbi.2017.11.010

Table 1.

Drug Information

Drugs	Description	Simulation Conditions
LMA	Low-melting point agarose, with different (%) concentration mimics mucus viscosity	Figure 3(c)
Apyrase	An enzyme that catalyzes ATP into AMP rapidly	Increase ATP reaction rate by 30 times in ATP model.
Bumetanide	An inhibitor of Cl secretion (affect both CaCC and CFTR)	The Cl⁻ secretion is 0; G_CaCC = 0 pSμm⁻², G_CFTR = 0 pSμm⁻².
8-SPT	8 (p-sulfophenyl) theophylline; an ADO receptor antagonist	Equivalent to [ADO]=0 nM
Nystatin	An ionophore that significantly increases Na absorption rate through membrane, bypassing ENaC	G_ENaC = 40 pSμm⁻²; a large conductance to mimic the permeabilized membrane.
Aprotinin	ENaC inhibiting protein, decrease Na absorption	No effect to NL model; G_ENaC*0.25 in CF model.
Trypsin	ENaC activating protein, increase Na absorption	G_ENaC*1.25 in NL model; No effect to CF model.
DIDS	4,4 -diisothiocyanostilbene-2,2 -disulfonic acid; CaCC antagonist	G_CaCC =0 pSμm⁻².
CFTR_inh172	CFTR antagonist	G_CFTR =0 pSμm⁻²