FIG. 5.

HS-AFM images of α-syn dimers. (a) The α-syn dimer consists of two compact monomers that move apart and come together as the experiment progresses. This type of dimer is termed type 1. The scale bar is 5 nm. (b) Cross-sectional analysis of the dimers clearly shows fluctuations in the peak-to-peak distance between the monomers. (c) The other type of dimer, type 2, consists of a globular monomer and another monomer that is able to form extended protrusion. The scale bar is 5 nm. (d) Cross sections of (c) showing the effect of protrusion in the α-syn monomer. All profiles start at the red circle and follow the dashed line.