Table 3.

Regions of significant working memory load‐associated degree centrality and local coherence change from baseline to 6‐week follow‐up in cardiac surgery patients and nonsurgical controls

Connectivity metrica	Locus (Brodmann areas)b	kE	SPM{T}	Local maximac
				x	y	z
Degree centrality (intrinsic connectivity contrast; ICC)	Left dorsal posterior cingulate cortex (BA 31)	156	4.59	−10	−70	30
			4.52	−2	−70	34
			4.36	0	−60	36
Local coherence (integrated local correlation; ILC)	Left and right dorsal posterior cingulate cortex (BA 31)	89	4.23	−2	−66	38
			3.72	6	−66	28

^aStatistical parametric mapping (SPM) mixed within‐/between‐subjects ANCOVA (Henson, 2015; Henson and Penny, 2005) of tbfMRI voxel‐wise intrinsic connectivity change (or integrated local correlation change) values between groups and two within‐subject factors (i.e., time and working memory load; i.e., 2 > 1‐back), adjusting for sex, perioperative global white matter hyperintensity volume change, and N‐back performance accuracy change [surgical patients (n = 25), controls (n = 26); cluster‐defining peak voxel threshold t ≥ 3.29 (p < .001) and family‐wise error‐corrected cluster spatial extent threshold (k_E) p‐FWE < .05].

^bAnatomical and Brodmann area labels based upon 7 mm³ search range of the Talairach Daemon Database using MNI‐to‐Talairach nonlinear transform coordinates (Lancaster et al., 2000).

^cMontreal Neurological Space (MNI) ICBM152 nonlinear 6th generation brain atlas coordinates.