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. 2018 Jan 11;13:17. doi: 10.1186/s11671-017-2420-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — SLNs characterization. Transmission electron microscopy (TEM) images showing the morphology of sorafenib nanoparticles with DOTAU (a) and inset (b). Example of a DOTAU-based SLN featuring a size of 327 by 172 nm (arrows), which confirm an average size of 304 nm as measured by DLS (d). c Example of TEM image showing diC₁₆dT-SLNs (arrows 330 by 500 nm, respectively). (e) TEM image of a SLN-. I & II spots are the localisations where EDX acquisitions was performed. (f) EDX spectra at I & II positions. Dashed line emphasized the emission of chlorine atom, which is only present in I. Chemical structure of Sorafenib molecule is also presented. Both spectra were normalized with Cu atom emission at 8 keV (due to TEM Cu grid)