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. 2018 Jan 11;8:480. doi: 10.1038/s41598-017-18867-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Animals treated with MSCEVs displayed significantly higher locomotor recovery scores when compared to sham and untreated SCI animals. At 5, 7 and 14 days post-injury, SCI + MSCEvs animals had significant improvement compared to untreated SCI (***p < 0.001, **p < 0.01, **p < 0.01, respectively). Treatment with MSCEVs results in significant functional improvement as early as 5 days following SCI. A linear regression was performed for both SCI + Vehicle and SCI + MSCEVs data (not shown). An increase in positive slope associated with SCI + MSCEVs compared to that of SCI + Vehicle indicates an increased rate of recovery (m = 1.1773, m = 1.0385, respectively). All data represented are means +/− SD. Sham + Vehicle, n = 6, SCI + Vehicle, n = 6, SCI + MSCEvs, n = 16. Data was statistically analyzed using Two-Way ANOVA with Tukey’s multiple comparison test.