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. 2018 Jan 11;8:480. doi: 10.1038/s41598-017-18867-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Animals treated with MSCEv⁺ exhibited significantly higher force threshold (**p < 0.01) than those treated with MSCEv^wt when tested with the Dixon Up-Down method for mechanical sensitivity in the hind paws. There was also a significant increase in threshold when treated with MSCEv^wt (*p < 0.05), when compared to untreated SCI animals. All data was analyzed for statistical significance using One-Way ANOVA with Sidak’s test for multiple comparisons. Sham + Vehicle, n = 6, SCI + Vehicle, n = 6, SCI + MSCEv^wt, n = 8, SCI + MSCEv⁺, n = 8. Data represent mean values +/− SEM.