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. 2018 Jan 11;8:480. doi: 10.1038/s41598-017-18867-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flow cytometry of spleen tissue and blood samples from each animal provide evidence of anti-inflammatory effects of MSCEv^wt/MSCEv⁺ treatment. Animals treated with either MSCEv^wt or MSCEv⁺ after SCI show approximately 5–10% decrease in MDSC present in the blood with an increase of approximately 10% in the spleen. This suggests that MSCEv^wt/MSCEv⁺ treatment causes a retention of MDSCs in the spleen that normally migrate to the blood after SCI. The opposite appears to occur with NK cells. MSCEv^wt and MSCEv⁺ treatment both result in a decrease of NK cells in the spleen following SCI but restore blood levels of NK cells to sham values. Both treatments also resulted in a decrease in splenic neutrophils, however, MSCEv⁺ caused a decrease in blood neutrophils to sham-like values. Both treatments recover myeloid cells that are decreased in both spleen and blood following SCI. Sham + Vehicle, n = 2, SCI + Vehicle, n = 2, SCI + MSCEv^wt, n = 3, SCI + MSCEv⁺, n = 3.