Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 11;8:420. doi: 10.1038/s41598-017-17981-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

FTVII-treatment improves efficacy of adoptive Treg therapy for GVHD in NSG mice. (A) NSG mice that had been injected with PBMC 14d earlier were injected with PBS (PBMC only) or suboptimal numbers (1.0 × 10⁵) of buffer- or FTVII- treated, expanded nvTregs/mouse (n = 6). The injection of FTVII-treated/expanded nvTregs significantly reduced the weight loss that is indicative of xenogeneic GVHD severity in NSG mice⁴⁶. (B) In contrast, when mice were given optimal (5.0 × 10⁵) doses of buffer- or FTVII- treated nvTregs, all Treg injected mice showed similar rescue from disease. RNA, isolated from the intestine (top) and bone marrow (bottom) isolated from mice that were still viable on day 50 after receiving the indicated treatments was examined for expression of (C) FoxP3, (D) IL-17, and (E) TNF-α relative to B₂M by real-time PCR. Correlation to weight loss as a measure of disease activity was determined by linear regression analysis. Data shown are mean ± SEM. Significance, determined by Student’s t test, is indicated by (*P < 0.05), (**P < 0.01), and (***P < 0.001).