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. 2018 Jan 11;8:546. doi: 10.1038/s41598-017-18699-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity Skin Disease Network of MSP: A detailed breakdown of the gene hits in the skin disease pathways, their associations with each other and subcellular location. The skin diseases included in these pathways are: psoriasis, chronic psoriasis, exanthem of skin, plaque psoriasis, Acne, Dermatitis, advanced stage atopic dermatitis, atopic dermatitis, Netherton syndrome, acne vulgaris, nodular melanoma, keratosis, infection of skin, superficial spreading melanoma, basal-cell carcinoma, hidradenitis suppurativa, senile lentigo, psoriasiform dermatitis, acral lentiginous melanoma cancer, dermatofibroma, seborrheic keratosis. This figure highlights that MSP contains more network connections than the other proteomes assessed (PaxDB and Bliss data in full–Supplementary Fig. 2).