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. 2018 Jan 11;8:469. doi: 10.1038/s41598-017-18801-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Micro-CT and histological analysis of the proximal tibia growth plate in WT and Ach mice. 3D reconstructions of the proximal tibia growth plates were generated from micro-CT images to calculate the growth plate volume (A,B) and thickness (C,D) in 3- and 6-week-old mice. The ratio of the growth plate volume to thickness is summarized in (E). (F) Representative growth plates from 3-week WT and Ach groups showing topographical contours of growth plate thickness. (G) H&E of 3-week-old growth plates show narrow proliferative (red bracket) and hypertrophic (yellow bracket) zones in Ach mouse compared to WT mouse. Scale bars: 100μm. The graphical data are represented as mean ± SEM (**0.001 < p < 0.01, ****p < 0.0001).