Table 3.

The function that is most highly correlated with the MICs for each antibiotic.

Antibiotic	PATRIC Function	PCC Actual MICa	PCC Predicted MICb	Top 10 Coveragec
Meropenem	Class A beta-lactamase (EC 3.5.2.6) => KPC family, carbapenem-hydrolyzing	0.923	0.814	0.7
Trimethoprim Sulfamethoxazole	Dihydropteroate synthase type-2 (EC 2.5.1.15) @ Sulfonamide resistance protein	0.919	0.758	0.9
Imipenem	Class A beta-lactamase (EC 3.5.2.6) => KPC family, carbapenem-hydrolyzing	0.891	0.905	0.8
Cefepime	Class A beta-lactamase (EC 3.5.2.6) => CTX-M family, extended-spectrum	0.848	0.648	0.9
Tobramycin	Aminoglycoside N(6′)-acetyltransferase (EC 2.3.1.82) => AAC(6′)-Ib/AAC(6′)-II	0.837	0.853	0.8
Tetracycline	Tetracycline resistance regulatory protein TetR	0.829	0.717	0.8
Ceftriaxone	Class A beta-lactamase (EC 3.5.2.6) => CTX-M family, extended-spectrum	0.823	0.700	0.7
Gentamicin	Aminoglycoside N(3)-acetyltransferase (EC 2.3.1.81) => AAC(3)-II,III,IV,VI,VIII,IX,X	0.818	0.862	0.6
Ampicillin Sulbactam	Class A beta-lactamase (EC 3.5.2.6) => TEM family	0.780	0.787	0.8
Ciprofloxacin	Integron integrase IntI1	0.715	0.713	0.8
Aztreonam	Integron integrase IntI1	0.678	0.614	0.7
Cefazolin	Class A beta-lactamase (EC 3.5.2.6) => CTX-M family, extended-spectrum	0.676	0.667	0.9
Cefuroxime sodium	Aminoglycoside N(3)-acetyltransferase (EC 2.3.1.81) => AAC(3)-II,III,IV,VI,VIII,IX,X	0.668	0.616	0.3
Ceftazidime	Integron integrase IntI1	0.657	0.623	0.6
Levofloxacin	probable bacteriophage protein STY1063	0.588	0.584	0.7
Piperacillin Tazobactam	plasmid stabilization system	0.583	0.501	0.1
Amikacin	IncI1 plasmid conjugative transfer prepilin PilS	0.577	0.478	0.2
Cefoxitin	Class A beta-lactamase (EC 3.5.2.6) => KPC family, carbapenem-hydrolyzing	0.550	0.571	0.6
Nitrofurantoin	Integron integrase IntI1	0.433	0.507	0.6
Ampicillin	Class A beta-lactamase (EC 3.5.2.6) => TEM family	0.357	0.327	0.0

^aPearson correlation coefficient between the occurrences of the given function and the actual MICs.

^bPearson correlation coefficient between the occurrences of the given function and the predicted MICs.

^cThe fraction of the top 10 functions (by PCC) for the predicted MICs that occur in the top 10 for the actual MICs.