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. 2018 Jan 11;8:498. doi: 10.1038/s41598-017-18985-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations between intron removal and protein expression. (A) Functional networks showing pathways affected by upregulated proteins whose corresponding transcripts underwent intron removal upon platelet stimulation with COLL (left networks) or TRAP (right networks). (B) IGV screen-shots showing differentially retained introns in resting and activated platelets in transcript regions and the corresponding peptide sequence mapping on exon/exon junctions identified after activation. (C) Heatmap showing downregulated introns (yellow/blue heatmap) and the corresponding exon/exon junction peptide changes following activation (red heatmap) after activation with COLL and/or TRAP. Gray: not statististically significant.