Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 11;8:545. doi: 10.1038/s41598-017-19071-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Renal distribution of caveolin 1 in wild-type mouse kidney. (a,b) Representative bright-field images showing basolateral caveolin 1 (Cav1) distribution along renal distal epithelia (a) as well as a Cav1 signal in medullary vasculature (b); immunoperoxidase/hematoxylin staining, interference contrast. (c,d) Double immunofluorescence staining for Cav1 and Na-K-2Cl cotransporter (NKCC2) shows the transition between NKCC2-positive thick ascending limb (TAL) and NKCC2-negative early distal convoluted tubule (DCT1; bar); TAL and DCT1 are Cav1-negative. (e,f) Immunofluorescence staining for Cav and, on a consecutive section, for DCT-specific Na-Cl cotransporter (NCC) showing the transition between NCC-positive late DCT (DCT2) and ensuing NCC-negative connecting tubule (CNT); moderate basolateral Cav1 signal is detected in DCT2 (arrows); stronger Cav1 signal is observed in CNT principal cells. (g,h) Double immunofluorescence staining for Cav1 and aquaporin 2 (AQP2) shows a moderate Cav1 signal in AQP2-negative DCT2 (arrows) and a stronger Cav1 signal in CNT and collecting duct (CD) principal cells (bars indicate DCT2/CNT and CNT/CD transitions).