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. 2018 Jan 11;8:429. doi: 10.1038/s41598-017-18888-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Green tea extract attenuated the activation of Müller glial cells. (a–c) GFAP staining labelled a dense layer of astrocytes and a few Müller glia processes that run through the whole thickness of the retina in control group. (b) IBA-1 staining showed the localization of a few microglia in the ganglion cell layer (GCL) and inner nuclear layer (INL). (c–f) After LPS insult, the expression of GFAP in Müller glia cells was elevated obviously, which accompanied by an increase in microglial cells in GCL and INL. (g–l) GTE treatments attenuated the intensity of GFAP staining and density of IBA-1 staining dramatically, especially in high dose group. (m) Measurement of the fluorescence intensity in these tissues showed GTE produced a dose-dependent reduction of GFAP immunoreactivity. *p < 0.05, n = 6.