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. 2018 Jan 11;8:457. doi: 10.1038/s41598-017-18047-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemistry of articular cartilage 10 weeks after DMM surgery. Representative sections and histograms of the percentage of positive chondrocytes or matrix staining of cartilage degradation markers in medial tibial plateaus (A–E) from Optc ^+/+ and Optc ^−/− mice at 10 weeks after sham (control) and DMM surgery, counterstained with methyl green. Black arrowheads indicate stained area (A,B) or positive-stained cells (C,D,E). Bar in (A) = 100 μm. Original magnification X250. Values are the mean ± SEM of sham (control) (n = 6/group), DMM-Optc ^+/+ (n = 9) and DMM-Optc ^−/− (n = 8). p values were determined by Mann-Whitney test; only significant p values are shown except for those between sham and their respective DMM groups which are < 0.050. Negative controls are shown in Supplementary Material Fig. S10.