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. 2018 Jan 11;8:457. doi: 10.1038/s41598-017-18047-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ultrastructure of type II collagen fibers. Representative images obtained with transmission electron microscopy (TEM) of (A) cartilage, in which 1 indicates the upper zone and 2 the deep zone, and collagen fibers from (B) Optc ^+/+ and (C) Optc ^−/− mice at 10 weeks of age. Bar in (B) = 100 μm. Magnifications: (A) X1200 and (B,C) X30000. (D) Histograms represent the frequency of each fiber’s diameter and the average diameter of Optc ^+/+ and Optc ^−/− mice. (E) Picrosirius red staining of mouse cartilage from DMM-Optc ^+/+ and DMM-Optc ^−/− mice and the histogram representing the birefringence score. Values in graphs in (D,E) are mean ± SEM. p values were determined by Mann-Whitney test.