Table 4.
Clinical features and laboratory examinations of patients with isolated PPNAD and patients with CNC
| Isolated PPNAD | Carney syndrome | P-value | |
|---|---|---|---|
| Age (years) | 22.13 ± 9.91 | 19.56 ± 4.57 | 0.318 |
| Number | 16 | 9 | 0.667 |
| Female | 10 | 7 | |
| Male | 6 | 2 | |
| BMI (kg/m2) | 24.85 | 26.63 | 0.327 |
| Hypertension | 11 | 8 | 0.380 |
| Grade I | 3 | 2 | |
| Grade II | 2 | 3 | |
| Grade III | 6 | 3 | |
| IGT or DM | 9 | 5 | 1.000 |
| IGT | 8 | 4 | |
| DM | 1 | 1 | |
| TC (mmol/L) | 6.01 | 5.25 | 0.213 |
| TG (mmol/L) | 1.81 | 1.46 | 0.491 |
| LDL-C (mmol/L) | 3.81 | 3.03 | 0.122 |
| HDL-C (mmol/L) | 1.65 | 1.61 | 0.869 |
| Potassium (mmol/L) | 4.00 | 3.96 | 0.873 |
| Osteopenia or osteoporosis | 12 | 6 | 1.000 |
| Osteopenia | 3 | 1 | |
| Osteoporosis | 9 | 5 | |
| Severe osteoporosis | 2 | 1 | |
| Fatty liver | 5 | 3 | 1.000 |
| Adrenal gland CT | 4 with normal adrenal glands | 2 with normal adrenal glands | |
| 5 with unilateral nodules | 1 with unilateral nodules | ||
| 8 with bilateral nodules | 6 with bilateral nodules | ||
| 24 h UFC | |||
| Baseline | 375.05 (282.18, 411.40) | 423.10 (216.88, 622.96) | 0.301 |
| LDDST | 482.20 (344.96, 770.60) | 556.92 (389.86, 778.85) | 0.558 |
| HDDST | 485.42 (339.17, 745.01) | 862.90 (391.21, 948.76) | 0.229 |
| Post/Pre (L) | 1.31 (1.04, 1, 75) | 1.50 (0.79, 2.15) | 0.978 |
| Post/Pre (H) | 1.49 (1.12, 2.08) | 1.59 (1.05, 2.18) | 0.846 |
PPNAD pigmented nodular adrenocortical disease, BMI body mass index, IGT impaired glucose tolerance, DM diabetes mellitus, TC total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, 24 h UFC 24 h urinary free cortisol, Post/Pre (L) the ratio of 24 h UFC posterior to LDDST and prior to LDDST, Post/Pre (H) the ratio of 24 h UFC posterior to HDDST and prior to HDDS